AB171. Regeneration of rat corpus cavernosa tissue after transplantation of human bone-marrow-derived CD133+ cells
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چکیده
© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2015;4(S1) www.amepc.org/tau for 12 h, clusterin mRNA was markedly up-regulated after transfection with the control vector; however, the transfection of siRNA targeting clusterin resulted in <70% reduction in the expression of clusterin mRNA. Furthermore, the apoptotic index in these Sertoli cells was significantly higher after the treatment with siRNA targeting clusterin than control, and the most prominent difference was observed within 24 h after the heat treatment. Conclusions: These results suggest that an increase in the secretion of clusterin by Sertoli cells protects the testes from heat stress-induced injury.
منابع مشابه
Regeneration of rat corpora cavernosa tissue by transplantation of CD133+ cells derived from human bone marrow and placement of biodegradable gel sponge sheet
The objective is to develop an easier technique for regenerating corpora cavernosa tissue through transplantation of human bone marrow-derived CD133 + cells into a rat corpora cavernosa defect model. We excised 2 mm × 2 mm squares of the right corpora cavernosa of twenty-three 8-week-old male nude rats. Alginate gel sponge sheets supplemented with 1 × 10 4 CD133 + cells were then placed over th...
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Sufficient angiogenesis is crucial during tissue regeneration and therefore also pivotal in bone defect healing. Recently, peripheral blood derived progenitor cells have been identified to have in addition to their angiogenic potential also osteogenic characteristics, leading to the hypothesis that bone regeneration could be stimulated by local administration of these cells. The aim of this stu...
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© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2015;4(S1) www.amepc.org/tau corpus cavernosa in the horizontal direction. In the CD rat, we observed the tissue of the regenerated corpus cavernosa, the structure resembled that of the SH rat in appearance of HE-stained tissue. Immunohistochemical analysis revealed that, in the SH rat, vascular smooth muscles were ...
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